Construction and evaluation of ratiometric fluorescent probes based on a 7-aminocoumarin scaffold for the detection of SO2 derivatives. (February 2022)

• Record Type: Journal Article
• Authors: Shen, Weiliang; Hu, Guoxing; Xu, Hanhan; Sun, Wei; Hu, Yonghong; Yang, Wenge
• Is Part Of: Dyes and pigments. Volume 198(2022)
• Publication Date: 2022-02
• Subjects: Fluorescent probe -- SO2 derivatives -- FRET -- Coumarin; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2021.109971
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: As a signal molecule, SO2 participates in many complex physiological processes. Therefore, in view of the addition properties of SO2 derivatives to unsaturated olefins, we reasonably designed a set of ratiometric fluorescent probes (NB1, NB2, NB3), and evaluated the influence of the coumarin moiety on the optical properties of the probes. Amongst the probes when the 7-position is substituted by a fused quinolizine (julolidine) unit, the probe NB2 shows a change from red to green fluorescence upon reaction with SO2, and has excellent optical properties: 136 nm emission band gap, 230 s response time, high selectivity, and excellent sensitivity. More valuable is the fact that NB2 can be used in cell imaging experiments, real sample detection, and employed to prepare fluorescent test paper for the qualitative test of SO2 gas, indicating that NB2 can be used as a powerful tool for the detection of SO2 derivatives. Graphical abstract: Image 1 Highlights: The effect of the terminal group on the probe properties was studied. NB2 can quantitatively detect sulfite over a wide concentration range. NB2 has been applied to biological imaging in living cells.