A tale of two pandemics: enhancing the immune system by addressing sedentary behaviors. (September 2021)

• Record Type: Journal Article
• Authors: Kallen, Victor; Scherder, Rogier; Cramer, Maarten-Jan; Stam, Jacqueline; Scherder, Erik
• Is Part Of: Psychoneuroendocrinology. Volume 131(2021)Supplement
• Publication Date: 2021-09
• Subjects: Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2021.105487
• Languages: English
• ISSNs: 0306-4530

Abstract

Abstract : Background: The prognosis after a Sars-Cov-2 infection is substantially worse for individuals suffering from a non-communicable disease associated with the rampant sedentary pandemic characterized by insufficient physical activity (e.g. cardiovascular disease, obesity, diabetes). The HPA-axis, a prominent structure in aligning metabolic and inflammatory processes, is considered instrumental in this relation. Methods: However, theoretically this provides a promising opportunity to strengthen immune functioning: reversing sedentary behaviors. A literature review was performed to investigate this hypothesis. Results: Scientific evidence shows that interrupting prolonged sitting combined with moderately intensive exercise (~30 minutes every day: walking, cycling), potentially extended with 2/3 sports activities every week (~45 minutes, Heart Rate Reserve ~70%), provides an optimal exercise protocol to support immune functioning. Small but significant positive effects on immune markers are generally reported within 3 to 12 weeks. Conclusion: On a population scale and under pandemic conditions reducing sedentary behaviors and promoting physical exercise are likely to have a significant positive effect on the overall health prognosis.