Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues. Issue 1 (5th November 2021)

• Record Type: Journal Article
• Authors: Van Nieuwenhove, Carina P.; del Huerto Moyano, Andrea; Van Nieuwenhove, Guido A.; Molina, Verónica; Luna Pizarro, Patricia
• Is Part Of: Lipids. Volume 57:Issue 1(2022)
• Page Start: 33
• Page End: 44
• Publication Date: 2021-11-05
• Subjects: availability -- conjugated linoleic acid -- conjugated linolenic acid -- fatty acid profile -- Jacaranda mimmosifolia -- jacaric acid -- nutraceuticals -- serum biomarkers; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1002/lipd.12327
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO), is considered a potent anticarcinogenic agent. Several studies have focused on its biological effects, but the metabolism once consumed is not clear yet. The aim of this work was to evaluate the effects of two different daily doses of JO on serum parameters and fatty acid (FA) profile of mice tissues after 4 weeks of feeding. No significant changes on body weight gain, food intake, or tissue weight were determined after 0.7 or 2 ml/kg of JO supplementation compared to control animals. Significantly lower blood low‐density lipoproteins‐cholesterol (20 mg/dl) and glucose (~147–148 mg/dl) levels were detected in both oil‐treated groups compared to control (31.2 and 165 mg/dl, respectively). Moreover, jacaric acid was partially converted into cis 9, trans 11 conjugated linoleic acid (CLA) and thus further incorporated into tissues. Liver evidenced the highest total conjugated fatty acid content (1.1%–2.2%), followed by epididymal (0.7%–1.9%) and mesenteric (1.4%–1.8%) fat. Lower saturated and higher unsaturated fatty acid content was detected in both oil‐treated groups compared to control. Our results support the safety of JO and its potential application with a functional or nutraceutical propose, by increasing human CLNA consumption and further availability of CLA.