Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging. (23rd July 2021)

• Record Type: Journal Article
• Authors: Chen, Can; Ge, Jianxian; Gao, Yun; Chen, Lei; Cui, Jiabin; Zeng, Jianfeng; Gao, Mingyuan
• Is Part Of: Wiley interdisciplinary reviews. Volume 14:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-23
• Subjects: contrast agents -- iron oxide nanoparticles -- magnetic resonance imaging -- ultrasmall; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; Biotechnology -- Periodicals; Ultrastructure (Biology) -- Periodicals; 610.28
• DOI: 10.1002/wnan.1740
• Languages: English
• ISSNs: 1939-5116

Abstract

Abstract: As a research hotspot, the development of magnetic resonance imaging (MRI) contrast agents has attracted great attention over the past decades for improving the accuracy of diagnosis. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with core diameter smaller than 5.0 nm are expected to become a next generation of contrast agents owing to their excellent MRI performance, long blood circulation time upon proper surface modification, renal clearance capacity, and remarkable biosafety profile. On top of these merits, USPIO nanoparticles are used for developing not only T1 contrast agents, but also T2 /T1 switchable contrast agents via assembly/disassembly approaches. In recent years, as a new type of contrast agents, USPIO nanoparticles have shown considerable applications in the diagnosis of various diseases such as vascular pathological changes and inflammations apart from malignant tumors. In this review, we are focusing on the state‐of‐the‐art developments and the latest applications of USPIO nanoparticles as MRI contrast agents to discuss their advantages and future prospects. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Abstract : The schematic illustrates the unique advantages of ultrasmall superparamagnetic iron oxide nanoparticles including outstanding magnetic resonance imaging performance, long blood circulation time, renal clearance capacity, and excellent biosafety.