A dynamic decision model for diagnosis of dementia, Alzheimer's disease and Mild Cognitive Impairment. (November 2020)

• Record Type: Journal Article
• Authors: Carvalho, Carolina M.; Seixas, Flávio L.; Conci, Aura; Muchaluat-Saade, Débora C.; Laks, Jerson; Boechat, Yolanda
• Is Part Of: Computers in biology and medicine. Volume 126(2020)
• Publication Date: 2020-11
• Subjects: Dynamic decision model -- Clinical decision support system -- Computer-aided diagnosis -- Dementia -- Alzheimer's disease -- Mild cognitive impairment; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2020.104010
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: CDSS (Clinical Decision Support System) is a domain within digital health that aims at supporting clinicians by suggesting the most probable diagnosis based on knowledge obtained from patient data. Usually, decision models used by current CDSS are static, i.e., they are not updated when new data are included, which could allow them to acquire new knowledge and enhance system accuracy. This paper proposes a dynamic decision model that automatically updates itself from classifier models using supervised machine learning algorithms. Our supervised learning process ranks several decision models using classifier performance measures, considering available patient data, filled by the health center, or local clinical guidelines. The decision model with the best performance is then selected to be used in our CDSS, which is designed for the diagnosis of D (Dementia), AD (Alzheimer's Disease), and MCI (Mild Cognitive Impairment). Patient datasets from CAD (Center for Alzheimer's Disease), at the Institute of Psychiatry of UFRJ (Federal University of Rio de Janeiro), and CRASI (Center of Reference in Attention to Health of the Elderly), at Antonio Pedro Hospital of UFF (Fluminense Federal University), are used. The main conclusion is that the proposed dynamic decision model, which offers the ability to be continuously refined with more recent diagnostic criteria or even personalized according to the local domain or clinical guidelines, provides an efficient alternative for diagnosis of Dementia, AD, and MCI. Highlights: The dynamic decision model learns with new clinical cases. The supervised learning process considers new attributes to build the decision model. Multicentric study useable for discrete or continuous variables. CDSS for diagnosing Dementia, Alzheimer's, and Mild Cognitive Impairment. Client application available on mobile devices.