COT-13 Luminance analysis of 5-aminolevulinic acid using Image J for malignant brain tumor. (6th December 2021)

• Record Type: Journal Article
• Authors: Kon, Takashi; Kobayashi, Yusuke; Sato, Yosuke; Shimizu, Katsuyoshi; Mizutani, Tohru
• Is Part Of: Neuro-oncology advances. Volume 3(2021)Supplement 6
• Page Start: vi30
• Page End: vi30
• Publication Date: 2021-12-06
• Subjects: 5-ALA -- malignant brain tumor -- fluorescenceーguided surgery; 616.99481
• DOI: 10.1093/noajnl/vdab159.117
• Languages: English
• ISSNs: 2632-2498

Abstract

Abstract: Purpose: For malignant brain tumor surgery, photodynamic diagnosis (PDD) with 5-aminolevulinic acid (5-ALA) is useful for maximal removal of the tumor. Although it has the advantage of identifying the presence or absence of residual tumors during surgery, there are variations in positive rates, and the classification is limited, based on visual inspection such as Stummer's classification (strong, vague, none). We analyzed the luminance of positive findings using software Image J for brain tumor surgery using 5-ALA, and we report the results. Materials and Methods: From April 2018 to March 2021, 31 patients with suspected malignant glioma before surgery were included. Intraoperative 5-ALA positive findings were analyzed by software Image J (Wayne Rasband: NIH), the luminance was measured with a histogram, and compared the maximum luminance titer. Results: Among the positive cases, the average maximum luminance value for malignant glioma was 101 (50–168), which consisted of 11 cases of Glioblastoma, 1 case of Oligodendroglioma, and 1 case of anaplastic astrocytoma. The average maximum brightness of metastatic brain tumors is lower than that of malignant gliomas, even if they are visually strong, 83.5 (28–121). Conclusions: Even if it is visually strong in the conventional Stummer classification, it may be possible to classify in detail by analyzing luminance with Image J. In addition, more objective index is necessary to classify the vague findings.