Advances in radiotherapy for brain metastases. (27th November 2021)

• Record Type: Journal Article
• Authors: Gondi, Vinai; Meyer, Jacquelyn; Shih, Helen A
• Is Part Of: Neuro-oncology advances. Volume 3(2021)Supplement 5
• Page Start: v26
• Page End: v34
• Publication Date: 2021-11-27
• Subjects: brain metastases -- modern management -- radiotherapy -- stereotactic radiosurgery -- whole-brain radiotherapy; 616.99481
• DOI: 10.1093/noajnl/vdab126
• Languages: English
• ISSNs: 2632-2498

Abstract

Abstract: As novel systemic therapies yield improved survival in metastatic cancer patients, the frequency of brain metastases continues to increase. Over the years, management strategies have continued to evolve. Historically, stereotactic radiosurgery has been used as a boost to whole-brain radiotherapy (WBRT) but is increasingly being used as a replacement for WBRT. Given its capacity to treat both macro- and micro-metastases in the brain, WBRT has been an important management strategy for years, and recent research has identified technologic and pharmacologic approaches to delivering WBRT more safely. In this review, we outline the current landscape of radiotherapeutic treatment options and discuss approaches to integrating radiotherapy advances in the contemporary management of brain metastases.