A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells. Issue 82 (27th September 2019)

• Record Type: Journal Article
• Authors: Xiao, Heng; Fan, Huiling; Xu, Luming; Pei, Zhiyin; Lei, Shijun; Xu, Jinglei; Xi, Jiangbo; Wang, Guobin; Wang, Lin; Wang, Zheng
• Is Part Of: Chemical communications. Volume 55:Issue 82(2019)
• Page Start: 12352
• Page End: 12355
• Publication Date: 2019-09-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc06674h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report a new biofunctionalized nanoplatform based on hyaluronic acid-coated gold-nano-dot-decorated hollow carbon nanospheres (AuHCNs-HA) for microRNA imaging in living cells. Abstract : We report a new biofunctionalized nanoplatform based on hyaluronic acid-coated gold-nano-dot-decorated hollow carbon nanospheres (AuHCNs-HA) for microRNA imaging in living cells. Importantly, the HA-coated nanoplatform could be internalized into target cells via CD44 receptor-mediated endocytosis. It can be further applied for intracellular miR-21 imaging in CD44-positive colorectal cancer cells.