The BARA necessities of PtdIns 3-kinase activation in autophagy. Issue 6 (3rd June 2019)

• Record Type: Journal Article
• Authors: Chang, Chunmei; Young, Lindsey N.; Hurley, James H.
• Is Part Of: Autophagy. Volume 15:Issue 6(2019)
• Page Start: 1122
• Page End: 1123
• Publication Date: 2019-06-03
• Subjects: Cryoelectron microscopy -- hydrogen-deuterium exchange -- HIV -- human immunodeficiency virus -- Nef -- Rubicon -- Tat-BECN1 peptide; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2019.1596501
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Macroautophagy/autophagy is an evolutionarily conserved degradation system with fundamental biological functions. The activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complexes and the subsequent production of phosphatidylinositol 3-phosphate (PtdIns3P) are pivotal to autophagy. Using a combination of structural biology, biochemistry, and biophysics, we revealed how the non-catalytic subunit BECN1 serves as a membrane-binding switch in the regulation of PtdIns3K complexes and autophagy.