Expanding the activity spectrum of antiviral agents. Issue 5 (May 2019)

• Record Type: Journal Article
• Authors: Ianevski, Aleksandr; Andersen, Petter I.; Merits, Andres; Bjørås, Magnar; Kainov, Denis
• Is Part Of: Drug discovery today. Volume 24:Issue 5(2019)
• Page Start: 1224
• Page End: 1228
• Publication Date: 2019-05
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2019.04.006
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: Broad-spectrum antivirals target ≥3 viral diseases. 108 safe-in-man broad-spectrum antiviral agents were identified. These agents could reinforce the arsenal of available antiviral therapeutics. Abstract : Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.