Biconcave Carbon Nanodisks for Enhanced Drug Accumulation and Chemo‐Photothermal Tumor Therapy. Issue 8 (11th March 2019)

• Record Type: Journal Article
• Authors: Mu, Qingxin; Wang, Hui; Gu, Xinyu; Stephen, Zachary R.; Yen, Charles; Chang, Fei‐Chien; Dayringer, Christopher J.; Zhang, Miqin
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 8(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-11
• Subjects: carbon nanodisks -- combination therapy -- drug carriers -- enhanced tumor accumulation -- photothermal conversion; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201801505
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: It is considered a significant challenge to construct nanocarriers that have high drug loading capacity and can overcome physiological barriers to deliver efficacious amounts of drugs to solid tumors. Here, the development of a safe, biconcave carbon nanodisk to address this challenge for treating breast cancer is reported. The nanodisk demonstrates fluorescent imaging capability, an exceedingly high loading capacity (947.8 mg g −1, 94.78 wt%) for doxorubicin (DOX), and pH‐responsive drug release. It exhibits a higher uptake rate by tumor cells and greater accumulation in tumors in a mouse model than its carbon nanosphere counterpart. In addition, the nanodisk absorbs and transforms near‐infrared (NIR) light to heat, which enables simultaneous NIR‐responsive drug release for chemotherapy and generation of thermal energy for tumor cell destruction. Notably, this NIR‐activated dual therapy demonstrates a near complete suppression of tumor growth in a mouse model of triple‐negative breast cancer when DOX‐loaded nanodisks are administered systemically. Abstract : Biconcave carbon nanodisks (BCNs) are prepared via the dissolution of magnetic core using Fe3 O4 /carbon core/shell template nanoparticles, and show a faster uptake rate in 4T1 cells in vitro and demonstrate greater tumor accumulation in vivo than carbon nanospheres. The BCN demonstrates great potential as a multifunctional nanoplatform for simultaneous fluorescent imaging, near‐infrared, and pH‐responsive drug release and combined photothermo/chemotherapy.