"Step-Down Parametric Procedures for Testing Correlated Endpoints in a Group-Sequential Trial" by Yiyong Fu. (2nd January 2019)

• Record Type: Journal Article
• Authors: Wolbers, Marcel; Glimm, Ekkehard; Xi, Dong
• Is Part Of: Statistics in biopharmaceutical research. Volume 11:Number 1(2019)
• Page Start: 104
• Page End: 105
• Publication Date: 2019-01-02
• Subjects: parametric multiple testing -- multiple endpoints -- interim analyses; Pharmacy -- Statistical methods -- Periodicals; Pharmaceutical biotechnology -- Statistical methods -- Periodicals; Biopharmaceutics -- Periodicals; Biometry -- Periodicals; Pharmacy -- Statistical methods; Periodicals; 615.190727
• DOI: 10.1080/19466315.2018.1529614
• Languages: English
• ISSNs: 1946-6315

Abstract

Abstract: Fu (2018 ) developed a parametric consonant closed testing procedure for correlated endpoints in a group-sequential design. In their approach, correlations between endpoints are exploited leading to a proportional up-scaling of local significance levels from Holm's weighting scheme. We challenge the claim that the proposed calculation of the up-scaling factor leads to a test that protects the type I error in the group-sequential setting and outline two alternative approaches which do lead to exact error control.