An easy synthesis of small, stable and water-compatible superparamagnetic protein-specific molecularly imprinted nanoparticles. (17th January 2022)

• Record Type: Journal Article
• Authors: Griffete, Nébéwia; Michot, Laurent; Gonzato, Carlo
• Is Part Of: Polymer. Volume 239(2022)
• Publication Date: 2022-01-17
• Subjects: Magnetic nanoparticles -- Molecularly imprinted polymer -- Surface modification -- Protein; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2021.124446
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: We report the synthesis of small (below 100 nm), stable and water-compatible superparamagnetic molecularly imprinted nanocomposites using water-soluble, dithiocarbamate-based photoiniferters. These agents were adsorbed directly on the surface of maghemite nanoparticles and allowed the synthesis of thin layers of molecularly imprinted polymer able to specifically and selectively bind green fluorescent protein as a model protein. To the best or our knowledge, this is the first time that water soluble photoiniferters have been used to prepare this kind of imprinted materials. Graphical abstract: Synthesis of small, stable and water-compatible magnetic molecularly imprinted polymer suitable for in vivo applications. Image 1 Highlights: Stable and small magnetic molecularly imprinted nanoparticles suitable for nanomedicine. Water soluble RAFT agents for photopolymerization from magnetic nanoparticles surface. Selective and specific recognition of green fluorescent protein.