A new morphinandienone alkaloid from the stems of Fissistigma tungfangense. Issue 3 (1st February 2019)

• Record Type: Journal Article
• Authors: Zhou, Qi; Fu, Yan-Hui; Zhang, Yu-Qin; Wu, Shou-Yuan; Song, Xiao-Ping; Xu, Wei; Chen, Guang-Ying
• Is Part Of: Natural product research. Volume 33:Issue 3(2019)
• Page Start: 374
• Page End: 379
• Publication Date: 2019-02-01
• Subjects: Fissistigma tungfangense -- morphinandienone alkaloid -- fissistigmine A -- anti-rheumatoid arthritis -- anti-proliferative effect on synoviocytes; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1452011
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new morphinandienone alkaloid, fissistigmine A (1 ), together with three known alkaloids (2 −4 ), were isolated and identified from the stems of Fissistigma tungfangense . Among them, fissistigmine A (1 ) represents the first example of a novel naturally occurring morphinandienone alkaloid with a unique cleavage of the C-9−N-17 bond. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proliferative effects on synoviocytes in vitro . Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with an IC50 value of 114.6 ± 2.2 μM. Abstract :