Self-immolative systems for the disclosure of reactive electrophilic alkylating agents. Issue 36 (4th April 2019)

• Record Type: Journal Article
• Authors: Acton, Aaron L.; Leroux, Flavien; Feula, Antonio; Melia, Kelly; Sambrook, Mark R.; Hayes, Wayne; Russell, Andrew T.
• Is Part Of: Chemical communications. Volume 55:Issue 36(2019)
• Page Start: 5219
• Page End: 5222
• Publication Date: 2019-04-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09728c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report the design, synthesis and assessment of the first examples of self-immolative systems triggered by reactive non-acidic electrophilic agents such as alkyl or benzylic halides. Abstract : In this paper we report the design, synthesis and assessment of the first examples of self-immolative systems triggered by non-acidic electrophilic agents such as methyl, allyl or benzylic halides. These systems provide a visual colorimetric disclosure response upon exposure to these electrophilic reagents under mild, basic conditions without the need for the use of analytical instrumentation.