Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy. Issue 17 (1st April 2019)

• Record Type: Journal Article
• Authors: Kou, Zhu; Zhao, Penghe; Wang, Zhihao; Jin, Zhaokui; Chen, Lihua; Su, Bao-Lian; He, Qianjun
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 17(2019)
• Page Start: 2759
• Page End: 2765
• Publication Date: 2019-04-01
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00338j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Hydrogen therapy is an emerging and promising strategy for the treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2 ), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Abstract : Hydrogen therapy is an emerging and promising strategy for treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2 ), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Herein, we propose a nanomedicine strategy of imaging-guided tumour-targeted delivery and tumour microenvironment-triggered release of H2 to address this issue, and develop a kind of biocompatible carboxymethyl cellulose (CMC)-coated/stabilized Fe (Fe@CMC) nanoparticle with photoacoustic imaging (PAI), tumour targeting and acid responsive hydrogen release properties for cancer therapy. The Fe@CMC nanoparticles have demonstrated high intratumoural accumulation capability, high acid responsiveness, excellent PAI performance, selective cancer-killing effect and high bio-safety in vitro and in vivo . Effective inhibition of tumour growth is achieved by intravenous injection of the Fe@CMC nanoparticles, and the selective anti-cancer mechanism of Fe@CMC is discovered to be originated from the energy metabolism homeostasis regulatory function of the released H2 . The proposed nanomedicine-mediated hydrogen therapy strategy will open a new window for precise, high-efficacy and safe cancer treatment.