Progress in the treatment of Parkinson-Plus syndromes. (February 2019)

• Record Type: Journal Article
• Authors: Olfati, Nahid; Shoeibi, Ali; Litvan, Irene
• Is Part Of: Parkinsonism & related disorders. Volume 59(2019)
• Page Start: 101
• Page End: 110
• Publication Date: 2019-02
• Subjects: Parkinson-plus syndrome -- Multiple system atrophy -- Progressive supranuclear palsy -- Corticobasal degeneration -- Dementia with Lewy bodies; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2018.10.006
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) are the four major proteinopathic neurodegenerative disorders. Currently, there are no disease modifying therapies for these disorders. However, better understanding of the etiopathogenic mechanisms of these disorders has allowed the development of novel therapeutic approaches. These mainly include strategies directed to the pathologic conformational shift, seeding and aggregation, as well as transcellular spread of the proteins that aggregate in the brain which are α-synuclein and tau. Modulation of inflammatory responses and neuroprotection are also targets of interest. A number of clinical trials have been performed and others are ongoing or are planned to address the authentic need for disease modifying treatments. However, challenges exist in terms of accurate early clinical diagnostic criteria and robust outcome measures, and preclinical animal models that would best recapitulate human disease.