Trends in axillary lymph node dissection for early-stage breast cancer in Europe: Impact of evidence on practice. (June 2019)

• Record Type: Journal Article
• Authors: Garcia-Etienne, Carlos A.; Mansel, Robert E.; Tomatis, Mariano; Heil, Joerg; Biganzoli, Laura; Ferrari, Alberta; Marotti, Lorenza; Sgarella, Adele; Ponti, Antonio
• Is Part Of: Breast. Volume 45(2019)
• Page Start: 89
• Page End: 96
• Publication Date: 2019-06
• Subjects: Axillary lymph node dissection -- Axillary dissection -- Axillary surgery -- Axillary lymphadenectomy -- Positive sentinel node -- Z0011 -- Surgery for breast cancer; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2019.03.002
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: Background: Data from recently published trials have provided practice-changing recommendations for the surgical approach to the axilla in breast cancer. Patients with T1-2 lesions, treated with breast conservation, who have not received neoadjuvant chemotherapy and have 1–2 positive sentinel nodes (Z0011-criteria) may avoid axillary lymph node dissection (ALND). We aim to describe the dissemination of this practice in Europe over an extended period of time. Methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified cases fulfilling Z0011-criteria from 2005 to 2016 from 34 European breast centers and report trends in ALND. Data derived from Germany, Italy, Belgium, Switzerland, Austria, and Netherlands. Results: 6671 patients fulfilled Z0011-criteria. Rates of ALND showed a statistically significant decrease from 2010 (89%) to 2011 (73%), reaching 46% in 2016 (p < 0.001). After multivariable analysis, factors associated with higher probability of ALND were earlier year of surgery, younger age, increasing tumor size and grade, and being operated in Italy (p < 0.001). The minimum and maximal rates of ALND in the most recent two-year period (2015–2016) were 0% and 83% in two centers located in different countries (p < 0.001). Conclusion: Our study demonstrates, a decrease in rates of ALND that started after year 2010 through the end of the study period. Wide differences were observed among centers and countries indicating the need to spread unified clinical guidelines in Europe to allow for homogeneous evidence-based practice patterns. Highlights: Indications for axillary dissection in breast cancer have changed based on trials. Little evidence has been reported about change in practice in Europe. Axillary dissection rates decreased from 89% to 46% in a European dataset. Higher probability of axillary dissection was associated with: Earlier year of surgery. Younger age. Increasing tumor size and grade. Being operated in Italy. Minimum and maximal rates of dissection recently reported: 0% and 83% in two centers.