Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome. (2021)

• Record Type: Journal Article
• Authors: Chebly, Alain; Djambas Khayat, Claudia; Yammine, Tony; Korban, Rima; Semaan, Warde; Bou Zeid, Jessica; Farra, Chantal
• Is Part Of: Leukemia research reports. Volume 16(2021)
• Publication Date: 2021
• Subjects: Acute myeloid leukemia -- AML -- Septin -- MLL -- SEPT6; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2021.100277
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6 . The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML- MLL-SEPT6 cases.