A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Long, Hui; Yan, Qin-Fang; Hu, Ze-Hua; Zhang, Qiang; Chen, Yu; Li, Lu-Jun
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 1(2019)
• Page Start: 86
• Page End: 92
• Publication Date: 2019-01-02
• Subjects: Aquifoliaceae -- Ilex centrochinensis -- (2S)-7-methoxy-3′, 4′-dihydroxy-5, 8-quinoflavan -- cytotoxic activity -- anti-inflammatory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1453504
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new para-quinone-type flavan, (2S)-7-methoxy-3′, 4′-dihydroxy-5, 8-quinoflavan (1 ), together with three known compounds, were isolated from the leaves of Ilex centrochinensis . Their structures were elucidated by detailed spectroscopic analyses for new structure and in comparison with published data for known compounds. Moreover, the new compound was evaluated its cytotoxic and anti-inflammatory activities in vitro on LPS induced RAW 264.7 cells and the results showed that 1 has promising anti-inflammatory activities. Abstract :