Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus. Issue 3 (March 2019)

• Record Type: Journal Article
• Authors: Tirkes, Temel; Jeon, Christie Y.; Li, Liang; Joon, Aron Y.; Seltman, Ted A.; Sankar, Meghana; Persohn, Scott A.; Territo, Paul R.
• Is Part Of: Pancreas. Volume 48:Issue 3(2019)
• Publication Date: 2019-03
• Subjects: diabetes mellitus -- obesity -- pancreas -- steatosis -- BMI – body mass index -- CP – chronic pancreatitis -- MRCP – magnetic resonance cholangiopancreatography -- SAT – subcutaneous adipose tissue -- T2DM – type 2 diabetes mellitus -- VAT – visceral adipose tissue -- V/S – visceral-to-subcutaneous adipose tissue ratio; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001252
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objective: The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus. Methods: Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging. Results: Pancreatic fat fraction showed a direct correlation with fat within the visceral compartment ( r = 0.54). Patients with CP showed higher visceral fat ( P = 0.01) and pancreatic fat fraction ( P < 0.001): mild, 24%; moderate, 23%; severe CP, 21%; no CP group, 15%. Patients with type 2 diabetes mellitus showed higher pancreatic steatosis ( P = 0.03) and higher visceral ( P = 0.007) and subcutaneous fat ( P = 0.004). Interobserver variability of measuring fat by magnetic resonance imaging was excellent ( r ≥ 0.90–0.99). Conclusions: Increased visceral adipose tissue has a moderate direct correlation with pancreatic fat fraction. Chronic pancreatitis is associated with higher pancreatic fat fraction and visceral fat. Type 2 diabetes mellitus is associated with higher pancreatic fat fraction and visceral and subcutaneous adiposity. Abstract : Supplemental digital content is available in the text.