Electronic cigarette use is associated with depressive symptoms among smokers and former smokers: Cross-sectional and longitudinal findings from the Constances cohort. (March 2019)

• Record Type: Journal Article
• Authors: Wiernik, Emmanuel; Airagnes, Guillaume; Lequy, Emeline; Gomajee, Ramchandar; Melchior, Maria; Le Faou, Anne-Laurence; Limosin, Frédéric; Goldberg, Marcel; Zins, Marie; Lemogne, Cédric
• Is Part Of: Addictive behaviors. Volume 90(2019)
• Page Start: 85
• Page End: 91
• Publication Date: 2019-03
• Subjects: Cohort studies -- Depression -- Electronic nicotine delivery systems -- Nicotine -- Tobacco use -- Tobacco use cessation; Substance abuse -- Periodicals; Alcoholism -- Periodicals; Drug addiction -- Periodicals; Nicotine addiction -- Periodicals; Smoking -- Periodicals; Gambling -- Psychological aspects -- Periodicals; Electronic journals; 362.29
• DOI: 10.1016/j.addbeh.2018.10.021
• Languages: English
• ISSNs: 0306-4603

Abstract

Abstract: Aims: To examine the cross-sectional and longitudinal associations between depressive symptoms and electronic cigarette (e-cig) use in a large population-based sample while taking into account smoking status and sociodemographic confounders. Methods: Participants from the French Constances cohort were included from February 2012 to December 2016. Smoking status, e-cig use (never/ever/current) and nicotine concentration were self-reported. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regressions were used to provide odds ratios (ORs) and 95% confidence intervals (95%CI) of e-cig use according to depressive symptoms, adjusting for age, sex and education. Results: In cross-sectional analyses (n = 35, 337), depressive symptoms (i.e. a CES-D score ≥ 19) were associated with both ever (OR [95%CI]: 1.67 [1.53–1.82]) and current (1.73 [1.53–1.96]) e-cig use with a dose-dependent relationship (p-trend<0.001). In longitudinal analyses (n = 30, 818), depressive symptoms at baseline were associated with current e-cig use at follow-up (2.02 [1.72–2.37]) with a similar dose-dependent relationship. These associations were mainly significant among smokers or former smokers at baseline. Furthermore, among smokers at baseline, depressive symptoms were associated with dual consumption at follow-up (1.58 [1.41–1.77]), whereas among former smokers, they were associated with either smoking only (1.52 [1.34–1.73]) or e-cig use only (2.02 [1.64–2.49]), but not with dual consumption (1.11 [0.73–1.68]) at follow-up. Finally, depressive symptoms were positively associated with nicotine concentration among e-cig users at baseline. Conclusions: Depressive symptoms were positively associated with e-cig use in both cross-sectional and longitudinal analyses with a dose-dependent relationship. In addition, nicotine concentration and depressive symptoms were positively associated. Highlights: Depressive symptoms were positively associated with electronic cigarette use. For smokers at baseline, they were associated with co-use of tobacco at follow-up. For former smokers, a link was found with tobacco only or electronic cigarette only. Nicotine concentration and depressive symptoms were also positively associated.