Emerging rejuvenation strategies—Reducing the biological age. Issue 1 (31st December 2021)

• Record Type: Journal Article
• Authors: Zhang, Bohan; Trapp, Alexandre; Kerepesi, Csaba; Gladyshev, Vadim N.
• Is Part Of: Aging cell. Volume 21:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-31
• Subjects: aging -- biomarkers -- epigenetic clocks -- rejuvenation; Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.13538
• Languages: English
• ISSNs: 1474-9718

Abstract

Abstract: Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti‐aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic reduction in biological age, which can be assessed by biomarkers of aging, such as epigenetic clocks. We discuss known and putative rejuvenation interventions and comparatively analyze them to explore underlying mechanisms. Abstract : Emerging interventions have suggested that biological aging can be reversed rather than just attenuated, but the criteria for what it takes to achieve rejuvenation remain controversial. In this review, we discuss known and putative rejuvenation interventions, exploring their connections within the context of aging biomarkers. We suggest that the prerequisite for classifying an intervention as rejuvenating is a robust and reproducible reduction in biological age, which can be assessed by high‐dimensional trackers of aging such as epigenetic clocks.