Treatment outcome of doxorubicin versus idarubicin in adult acute myeloid leukemia. (2021)

• Record Type: Journal Article
• Authors: Sherif, Hemat Afifi; Magdy, Ahmed; Elshesheni, Heba Anees; Ramadan, Sherein Mahmoud; Rashed, Reham A.
• Is Part Of: Leukemia research reports. Volume 16(2021)
• Publication Date: 2021
• Subjects: Doxorubicin -- Idarubicin -- Acute myeloid leukemia; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2021.100272
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Purpose: The present study aimed to compare treatment outcome of idarubicin versus doxorubicin in combination with Ara-C as induction therapy for untreated AML patients. Patients and methods: This retrospective study included 143 patients with de novo AML. All patients received full dose of standard induction therapy (3 + 7) using anthracyclines (doxorubicin or idarubicin) and cytarabine. Results: The studied groups had comparable CR. No significant differences were noted between the studied groups regarding DFS and OS. The DXR group had significantly lower cost in comparison to IDA group. Conclusions: Idarubicin doesn't have a clear advantage over doxorubicin in treatment of AML.