Elective neck dissection in salivary gland malignancies: Systematic review and meta‐analysis. Issue 2 (4th December 2021)

• Record Type: Journal Article
• Authors: Yan, Flora; Lao, Wilson P.; Nguyen, Shaun A.; Sharma, Anand K.; Day, Terry A.
• Is Part Of: Head & neck. Volume 44:Issue 2(2022)
• Page Start: 505
• Page End: 517
• Publication Date: 2021-12-04
• Subjects: elective neck dissection -- occult nodal metastasis -- parotid cancer -- salivary gland cancer -- salivary gland malignancy; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26923
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: We defined the occult nodal metastasis (ONM) rate of clinical node‐negative salivary gland malignancies and examined the role of elective neck dissection (END). Meta‐analysis querying four databases, from inception of databases to March 25th, 2020. Fifty‐one studies with 11 698 patients were included. ONM rates were 64% for salivary ductal carcinoma (SDC), 51% for undifferentiated carcinoma, 34% for carcinoma ex‐pleomorphic adenoma (CXPA), 32% for adenocarcinoma not otherwise specified (ANOS), 31% for lymphoepithelial carcinoma (LE), 20% for mucoepidermoid carcinoma, 17% for acinic cell carcinoma, and 17% for adenoid cystic carcinoma. T3/T4 tumors had a 2.3 times increased risk of ONM than T1/T2 tumors. High‐grade tumors had a 3.8 times increased risk of ONM than low/intermediate‐grade tumors. ONM rates were exceedingly high for T3/T4, high‐grade, and undifferentiated, SDC, ANOS, CXPA, and LE tumors, indicating the potential role of END.