High prevalence of thyroid hormone autoantibody and low rate of thyroid hormone detection interference. Issue 1 (1st December 2021)

• Record Type: Journal Article
• Authors: Ni, Jiajia; Long, Yu; Zhang, Li; Yang, Qingqing; Kou, Chunjia; Li, Shuqi; Li, Jingyi; Zhang, Haiqing
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-01
• Subjects: autoimmune thyroid disease -- interference -- nonthyroid autoimmune diseases -- thyroid hormone autoantibody; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24124
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Objective: Thyroid hormone autoantibody (THAb) is a common antibody in autoimmune disease and can interfere with the detection of thyroid hormone (TH). There was no research reporting the prevalence of THAb in Chinese and the rate of THAb interfering with TH detection. Methods: We collected 114 patients with autoimmune thyroid disease (AITD) (Hashimoto's thyroiditis, 57 cases; Graves' disease, 57 cases), 106 patients with nonthyroid autoimmune diseases (NTAID), and 120 healthy subjects. According to the presence or absence of thyroid antibodies, patients with NTAID were divided into two groups: NTAID‐AITD and NTAID groups. Radioimmunoprecipitation technique was used to detect THAb in all subjects. TH was detected on Abbot and Roche platforms in patients with positive THAb. Results: The prevalence of THAb was 22.8% in Hashimoto's thyroiditis and 45.6% in Graves' disease. The prevalence of THAb in AITD group was lower than that in NTAID or NTAID‐AITD groups (34.2% vs. 61.5%, p = 0.014; 34.2% vs. 71.3%, p < 0.01). Among total 98 patients with positive THAb, TH levels of 9 patients were falsely elevated (9.18%). Conclusion: The prevalence of THAb in AITD patients was lower than that in NTAID patients. Although THAb had a high frequency in various autoimmune diseases, the prevalence of THAb interfering with TH detection was only 9.18%. Abstract : We firstly investigated THAb in Chinese patients, and we found the prevalence of THAb in AITD patients was lower than that in NTAID patients. Although THAb has a high frequency in various autoimmune diseases, the rate of THAb interfering with thyroid hormone detection was only 9.18%.