Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population. Issue 1 (19th November 2021)

• Record Type: Journal Article
• Authors: Said, Rahma; Jenni, Rim; Boussetta, Sami; Ammous, Feryel; Zouari, Skander; Zaghbib, Selim; Chakroun, Marouene; Derouiche, Amine; Chebil, Mohamed; Ouerhani, Slah
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-19
• Subjects: Alu repeat sequence -- angiotensin conversion enzymes -- North Africa -- polymorphism -- prostate cancer -- Tunisia; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24129
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: Angiotensin‐converting enzyme ( ACE ) plays a pivotal role in several pathologies including cancers. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. We aimed to investigate for the first time, to our Knowledge, in North Africa the potential relationship between ACE I/D polymorphism with PC susceptibility and clinical outcomes of PC patients. Methods: This case‐control study included 143 healthy individuals and 124 patients diagnosed with PC. Using genomic DNA, the samples were genotyped for ACE I/D polymorphism by polymerase chain reaction (PCR). Results: We found that The D allele is significantly associated with an increased risk of PC and D/D + D/I genotypes were at 3 times increased risk of PC ([ p = 0.005], OR = 2.95, IC 95% = 1.26–7.09) compared with I/I genotype ( p = 0.003, OR = 0.3, IC 95% = 0.12–0.74). We observed an association between D/D and D/I genotypes with advanced age (≥70 years) ( p = 0.014; r 2 = 0.22). Furthermore, there is a significant prediction of advanced Gleason score ≥8 based on epidemiological parameters and ACE genotype ( p = 0.000; R 2 = 0.349), although no significant association was observed with stage and metastasis. Conclusion: The ACE I/D polymorphism is likely to predispose to PC and could play a role in PC progression and aggressiveness. Abstract : The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. The ACE SNP rs 4646994 is likely to predispose to PC and aggressiveness in Tunisia population. This study provides valuable information for the diagnosis and prognosis of the risk of PC disease.