Anti-tuberculosis drug delivery for tuberculous bone defects. (2nd December 2021)

• Record Type: Journal Article
• Authors: Hua, Long; Qian, Hu; Lei, Ting; Liu, Wenbin; He, Xi; Zhang, Yu; Lei, Pengfei; Hu, Yihe
• Is Part Of: Expert opinion on drug delivery. Volume 18:Number 12(2021)
• Page Start: 1815
• Page End: 1827
• Publication Date: 2021-12-02
• Subjects: Anti-tuberculosis -- drug delivery -- osteogenesis -- target therapy -- tuberculous bone defect; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2021.2005576
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Traditional therapy methods for treating tuberculous bone defects have several limitations. Furthermore, systemic toxicity and disease recurrence in tuberculosis (TB) have not been effectively addressed. Areas covered: This review is based on references from September 1998 to September 2021 and summarizes the classification and drug-loading methods of anti-TB drugs. The application of different types of biological scaffolds loaded with anti-TB drugs as a novel drug delivery strategy for tuberculous bone defects has been deeply analyzed. Furthermore, the limitations of the existing studies are summarized. Expert opinion: Loading anti-TB drugs into the scaffold through various drug-loading techniques can effectively improve the efficiency of anti-TB treatment and provide an effective means of treating tuberculous bone defects. This methodology also has good application prospects and provides directions for future research.