Treatment preferences for primary membranous nephropathy: Results of a multinational survey among nephrologists in the South Asia Pacific region. Issue 1 (25th August 2021)

• Record Type: Journal Article
• Authors: Bose, Bhadran; Badve, Sunil V.; Johnson, David W.; Hawley, Carmel; Jha, Vivekanand; Reidlinger, Donna; Peh, Chen Au
• Is Part Of: Nephrology. Volume 27:Issue 1(2022)
• Page Start: 35
• Page End: 43
• Publication Date: 2021-08-25
• Subjects: cyclophosphamide -- cyclosporine -- membranous nephropathy -- rituximab -- survey; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.13953
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Aim: There is no clear consensus on how best to treat primary membranous nephropathy (PMN). This study aimed to ascertain prevailing views among nephrologists on their choice of immunosuppressive agents to treat this disease. Methods: The Australasian Kidney Trials Network conducted a multinational online survey among nephrologists from the South Asia‐Pacific region to identify prescribing practices to treat PMN. Survey questions focused on the types of immunosuppressive therapies used, preferred first‐line and second‐line therapies, indications for starting immunosuppressive therapy, the preferred mode of combining corticosteroid and cyclophosphamide, the use of serum phospholipase A2 receptor antibody testing in clinical practice, indications for anticoagulation, and interest in participating in future clinical trials in PMN. Results: One hundered fifty‐five nephrologists from eight countries responded to the online survey. The majority of them were senior nephrologists from Australia and India with significant experience managing patients with PMN. The combination of cyclophosphamide and corticosteroid was the preferred first‐line therapy. Of those who used this combination, only 34.8% followed the Kidney Disease Improving Global Outcomes (KDIGO) 2012 guidelines by adding intravenous methylprednisolone. The combination of calcineurin inhibitor with corticosteroid was the most common second‐line therapy. Most respondents considered prophylactic anticoagulation if serum albumin was less than 25 g/L. Most nephrologists were keen to participate in a clinical trial with a control arm consisting of cyclophosphamide and corticosteroids. Conclusion: The combination of corticosteroid with cyclophosphamide (without intravenous methylprednisolone) is the most commonly reported first‐line immunosuppressive therapy for the management of PMN. SUMMARY AT A GLANCE: This is a multinational online survey among 155 nephrologists from the South Asia‐Pacific region to identify prescribing practices to treat primary membranous nephropathy (PMN). The combination of corticosteroid with cyclophosphamide is the most commonly reported first‐line immunosuppressive therapy, in which only 34% followed the KDIGO 2012 guidelines by adding i.v. methylprednisolone. Combining calcineurin inhibitor with corticosteroid was the most common second‐line therapy.