Issue Information. Issue 1 (28th December 2021)

• Record Type: Journal Article
• Other Names: Chen Yujie guestEditor.
• Is Part Of: Journal of neurochemistry. Volume 160:Issue 1(2022)
• Page Start: 1
• Page End: 9
• Publication Date: 2021-12-28
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.15384
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : Front cover: Restoring the cerebral blood flow and minimizing the loss of neurons are the two main aims in acute stroke therapy, in order to preserve energy supply to the neurons and other cells in the brain. The brain's energy homeostasis is therefore an important target in stroke therapy. The various articles in this special issue "Stroke and Energy Metabolism" pinpoint the hotspots of energy metabolism changes following stroke, including disturbed cerebral blood circulation, mitochondrial dysfunction, programmed neuronal cell death, and cell‐cell communications for brain metabolism, to provide insights and toe‐holds for further research and clinical management of stroke patients. Image Content: Schematic showing fluid metabolic pathways after subarachnoid hemorrhage and key transporter mechanisms [Figure 4 from article "Fluid metabolic pathways after subarachnoid hemorrhage" by Zhou et al., included in this special issue. DOI: 10.1111/jnc.15458]. (Left) Fluid metabolic pathways after subarachnoid hemorrhage. After a ruptured aneurysm in the subarachnoid space, blood under highpressure rushes into the subarachnoid space and the nearby cistern, increasing intracranial pressure and decreasing cerebral blood flow. Haematoma and toxic metabolites combine to impact the function and structure of microcirculation. Cerebrospinal fluid circulation and flow is disrupted, while the driving ability of glymphatic system for interstitial fluid is weakened, which reduces the excretion efficiency of toxic metabolites in brain. (Right) Astrocytes host the hub function of key transporters during interstitial fluid transport. Astrocytes express various transporters to interact with neurons, axons, pia mater, blood vessels, and other astrocytes. In this paper, the transport of glucose, lactate and water by astrocytes through aquaporins, GLUT and monocarboxylate transporters is exemplified, to realize the dynamic regulation of energy metabolism in the microenvironment.Jiru Zhou, Peiwen Guo, Zongduo Guo, Xiaochuan Sun, Yujie Chen, Hua Feng (2022) Fluid metabolic pathways after subarachnoid hemorrhage. JNeurochem https://onlinelibrary.wiley.com/doi/10.1111/jnc.15458