New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Tran, Thanh-Nha; Sichaem, Jirapast; Nguyen, Van-Kieu; Nguyen, Huu-Hung; Cao, Truong-Tam; Nguyen, Thi-Phuong; Vo, Van-Giau; Niamnont, Nakorn; Nguyen, Ngoc-Hong; Duong, Thuc-Huy
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 523
• Page End: 530
• Publication Date: 2022-01-17
• Subjects: Euphorbiaceae -- Euphorbia antiquorum L -- ent-atisane diterpenoid -- α-glucosidase inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1789634
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent- atisane compounds, ent- 3 α -acetoxy-16 β, 17, 18-trihydroxyatisane (1 ) and ent- 3 α, 14, 16 β, 17-tetrahydroxyatisane (2 ) together with three known compounds, 20-deoxy-16-hydroxyingenol (3 ), ent- 14[S], 16 α, 17-trihydroxyatisan-3-one (4 ), and agallochaol C (5 ). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1–5 were evaluated for α -glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α- glucosidase with the IC50 values of 119.9, 135.5, and 134.3 µM, respectively. None showed activity in cytotoxicity assay. Abstract : UF0001