A new N-containing phenolic glycoside from Capsicum annuum L. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Song, Changwei; Yu, Changyan; Zhu, Xinting; Luo, Xirong; Zhang, Yong; Meng, Lingjie; Luo, Yong; Chang, Han; Qin, Cheng; Liu, Yun
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 546
• Page End: 552
• Publication Date: 2022-01-17
• Subjects: Capsicum annuum L -- new N-containing compound -- ECD spectra -- stereo configuration -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1789983
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new N -containing phenolic glycoside (1 ) and seven known compounds were isolated from the fruits of Capsicum annuum L. Their structures were elucidated by extensive spectroscopic methods including MS, 1D and 2D NMR (HSQC, HMBC, 1 H- 1 H COSY, etc.). The stereo configuration of the new compound was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1–8 were evaluated in vitro for their cytotoxic activities against HCT-116 cell line using Sulforhodamine B (SRB) assay, and the result showed only compound 6 displayed a weak inhibitory activity against HCT-116 (IC50 = 22.5 ± 3.3 mmol/mL). Abstract : UF0001