Dimeric hexylitaconic acids from the marine-derived fungus Aspergillus welwitschiae CUGBMF180262. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Han, Jiahui; Yang, Na; Wei, Shangzhu; Jia, Jia; Lin, Rui; Li, Jiangpeng; Bi, Hongkai; Song, Fuhang; Xu, Xiuli
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 578
• Page End: 585
• Publication Date: 2022-01-17
• Subjects: Marine-derived Aspergillus welwitschiae -- dimeric hexylitaconic acid -- anti-Helicobacter pylori; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1793152
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2, 5-dione (1 ), and two dimeric analogues asperwelwinates A and B (2 and 3 ), together with ten known compounds, asperitaconic acid C (4 ), kotanin (5 ) and orlandin (6 ), desertorin B (7 ), fonsecinone A (8 ), aurasperone A (9 ), asperpyrones B and C (10 a nd 11 ), aspernigrin B (12 ), and pyrophen (13 ), were isolated from a strain of Aspergillus welwitschiae CUGBMF180262. The structures of compounds 1–3 were determined by detailed analysis of HRMS, and 1D/2D NMR experiments, while the absolute configurations of 2 and 3 were determined by comparison of experimental and calculated electronic circular dichroism spectra. 2 and 3 were first reported dimeric hexylitaconic acid derivatives. Compounds 8, 9 and 11 showed moderate antibacterial activities against Helicobacter pylori with minimum inhibitory concentration (MIC) values of 16 μg/mL. Graphical Abstract: UF0001