A study on relationship between androgenetic alopecia and cardiovascular risk using high sensitivity C-reactive protein and galectin-3 in men with early onset baldness. (2nd January 2022)

• Record Type: Journal Article
• Authors: Sözen, Mehmet; Baldane, Süleyman; Abusoglu, Sedat; Kebapcılar, Levent; Kebapcılar, Ayşegül; Tunçez Akyürek, Fatma; Ünlü, Ali; İpekci, Süleyman Hilmi
• Is Part Of: Biomarkers. Volume 27:Number 1(2022)
• Page Start: 71
• Page End: 78
• Publication Date: 2022-01-02
• Subjects: Androgenetic alopecia -- cardiovascular disease -- inflammation -- hsCRP -- galectin-3 -- Hamilton-Norwood scale; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2021.2013539
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Objective: In this study, the objective was to evaluate the cardiovascular and metabolic effects in men with male pattern alopecia beginning before 30 years of age. Methods: Total of 81 people (41 androgenetic alopecia (AGA) and 40 healthy individuals) were included in the study. Twenty-four-hour ambulatory blood pressure (ABP) measurement, high sensitive C-reactive protein (hsCRP), galectin-3 were studied. Hamilton-Norwood scale (HNS) was used to determine the AGA types of the cases. Results: The mean age in the AGA and control groups was 30.3 ± 7.5 and 30.8 ± 6.0, respectively. Twenty-four-hour ABP measurements, hsCRP, and galectin-3 were similar in both groups. There was a positive correlation between HNS grade with age, BMI, triglyceride levels and fasting blood glucose levels in individuals with AGA. Similarly, there was a positive correlation between HNS grade with daytime pulse wave velocity and night-time reflection magnitude. A significant positive correlation was determined between hsCRP with BMI and waist circumference, and between galectin-3 with BMI, waist circumference, hip circumference, HOMA-IR in individuals with AGA. Conclusions: This study shows that AGA patients are similar to the normal population in terms of insulin resistance or metabolic syndrome components. However, hsCRP and galectin-3 appear to be associated with cardiovascular disease risk factors in individuals with AGA.