A new abietane-type diterpenoid and a new long-chain alkenone from fungus Daldinia sp. TJ403-LS1. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Lin, Shuang; Zhang, Xueke; Shen, Ling; Mo, Shuyuan; Liu, Junjun; Wang, Jianping; Hu, Zhengxi; Zhang, Yonghui
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 531
• Page End: 538
• Publication Date: 2022-01-17
• Subjects: Daldinia sp. TJ403-LS1 -- Xylariaceae -- secondary metabolites -- abietane-type diterpenoid -- long-chain alkenone; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1789638
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new abietane-type diterpenoid, dalterpenoid A (1 ), a new long-chain alkenone derivative, (3 E, 5 E, 10 E )-8-hydroxytrideca-3, 5, 10, 12-tetraen-2-one (2 ), together with six known compounds (3 –8 ), namely epi -guaidiol A (3 ), xylaranol A (4 ), daldinone C (5 ), trans -3, 4-dihydroxy-3, 4-dihydro-anofinic acid (6 ), ( R )-6-hydroxymellein (7 ), helicascolide A (8 ), were obtained from fungus Daldinia sp. TJ403-LS1, which was originally isolated from roots of the medicinally valuable plant Anoectochilus roxburghii . The structures of compounds 1 and 2 were established based on widespread spectroscopic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configuration of 1 was further confirmed by electronic circular dichroism (ECD) calculation. All new compounds were tested for the in vitro cytotoxicity against five human cancer cell lines. Abstract : UF0001