Glutaminase inhibitory activity of umbelliferone isolated from kabosu (Citrus sphaerocarpa Hort. ex Tanaka). Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Shimada, Atsumi; Ueno, Hiroshi; Inagaki, Masanori; Yoshimitsu, Hitoshi
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 605
• Page End: 609
• Publication Date: 2022-01-17
• Subjects: Citrus sphaerocarpa -- umbelliferone -- 5-(hydroxymethyl)-2-furaldehyde -- oxypeucedanin hydrate -- glutaminase inhibitor; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1788553
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Kabosu ( Citrus sphaerocarpa Hort. ex Tanaka) fruits have pleasant and fresh odors and have been used as raw materials for vinegar, seasonings, jams, marmalades and juices in Japan. The n -butanol extracts from kabosu fruits were prepared and a component in the extract was purified by column chromatography and HPLC to afford compounds 1 -3 . Three compounds, 5-(hydroxymethyl)-2-furaldehyde (1 ), umbelliferone (2 ) and oxypeucedanin hydrate (3 ), have been isolated from kabosu, and the structures of compounds 1 -3 were elucidated by 1 D and 2 D NMR as well as EI-MS. Compound 2 exhibited potent glutaminase inhibitory activity with an IC50 value of 1.33 mM. This is the first report on glutaminase inhibitory activity of 2 and the isolation of three compounds 1 -3 from kabosu fruits. Abstract : UF0001