Heterogeneous Pd/C-catalyzed, ligand free Suzuki–Miyaura coupling reaction furnishes new p-terphenyl derivatives. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Avula, Satya Kumar; Rehman, Najeeb Ur; Anwar, Muhammad U.; Aalthani, Ghanim; Csuk, Rene; Al-Harrasi, Ahmed
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 566
• Page End: 570
• Publication Date: 2022-01-17
• Subjects: Ligand-free catalysis -- aryl boronic acids -- Suzuki–Miyaura coupling reaction -- Pd/C -- heterogeneous catalysis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1791112
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A series of new para -terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/C-catalyzed two-fold Suzuki–Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (2a-i ). Nine new p -terphenyl derivatives (3a –i ) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy, 1 H and 13 C NMR spectroscopy, mass spectrometry, and in the case of compound 3 b, by X-ray diffraction method. The new derivatives were obtained in very good yields (78–91%). This synthetic facile route is envisioned to improve the preparation of p -terphenyl-based natural products. Abstract : UF0001