A new diterpenoid from the leaves of Phyllanthus acidus. Issue 2 (17th January 2022)

• Record Type: Journal Article
• Authors: Duong, Thuc-Huy; Trung, Nguyen Tien; Phan, Cam-Tu Dang; Nguyen, Vu-Duy; Nguyen, Hoang-Chuong; Dao, Thi-Bich-Ngoc; Mai, Dinh-Tri; Niamnont, Nakorn; Tran, Thi-Ngoc-Mai; Sichaem, Jirapast
• Is Part Of: Natural product research. Volume 36:Issue 2(2022)
• Page Start: 539
• Page End: 545
• Publication Date: 2022-01-17
• Subjects: Phyllanthaceae -- Phyllanthus acidus -- phyllane C -- diterpenoid -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1789980
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new diterpenoid, phyllane C (1 ), along with three known compounds, ovoideal E (2 ), spruceanol (3 ), and fluacinoid B (4 ) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1 . Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL). Graphical Abstract: UF0001