Domestication Shapes Recombination Patterns in Tomato. (1st October 2021)

• Record Type: Journal Article
• Authors: Fuentes, Roven Rommel; de Ridder, Dick; van Dijk, Aalt D J; Peters, Sander A
• Editors: Purugganan, Michael
• Is Part Of: Molecular biology and evolution. Volume 39:Number 1(2022)
• Publication Date: 2021-10-01
• Subjects: domestication -- selective sweeps -- structural variants -- transposable elements -- recombination -- heterochromatin; Molecular biology -- Periodicals; Molecular evolution -- Periodicals; Evolution, Molecular -- Periodicals; Molecular Biology -- Periodicals; 572.8
• DOI: 10.1093/molbev/msab287
• Languages: English
• ISSNs: 0737-4038

Abstract

Abstract: Meiotic recombination is a biological process of key importance in breeding, to generate genetic diversity and develop novel or agronomically relevant haplotypes. In crop tomato, recombination is curtailed as manifested by linkage disequilibrium decay over a longer distance and reduced diversity compared with wild relatives. Here, we compared domesticated and wild populations of tomato and found an overall conserved recombination landscape, with local changes in effective recombination rate in specific genomic regions. We also studied the dynamics of recombination hotspots resulting from domestication and found that loss of such hotspots is associated with selective sweeps, most notably in the pericentromeric heterochromatin. We detected footprints of genetic changes and structural variants, among them associated with transposable elements, linked with hotspot divergence during domestication, likely causing fine-scale alterations to recombination patterns and resulting in linkage drag.