Clinical significance of part-solid lung cancer in the eighth edition TNM staging system. (25th September 2021)

• Record Type: Journal Article
• Authors: Okamoto, Tatsuro; Miyawaki, Michiyo; Toyokawa, Gouji; Karashima, Takashi; Abe, Miyuki; Takumi, Yohei; Hashimoto, Takafumi; Osoegawa, Atsuhi; Tagawa, Tetsuzo; Takeuchi, Hideya; Shimokawa, Mototsugu; Sugio, Kenji
• Is Part Of: Interactive cardiovascular and thoracic surgery. Volume 34:Number 2(2022)
• Page Start: 219
• Page End: 226
• Publication Date: 2021-09-25
• Subjects: Non-small-cell lung cancer -- Staging system -- Surgery -- Prognosis -- Part-solid tumour; Chest -- Surgery -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.1
• DOI: 10.1093/icvts/ivab255
• Languages: English
• ISSNs: 1569-9293

Abstract

Abstract : The tumour, node and metastasis (TNM) staging system has been one of the most practical and important prognostic predictors of lung cancer for several decades [1, 2]. Abstract: : OBJECTIVES: The ground-glass component of part-solid tumour (PST) was eliminated as a clinical T (cT) descriptor in the eighth edition of the tumour, node and metastasis (TNM) staging system. We aimed to validate the new cT descriptor and investigate the prognostic impact of PST in the new staging system. METHODS: Non-small-cell lung cancer (NSCLC) patients ( n = 1061) who underwent lung resection and were available for the assessment of thin-section computed tomography images were retrospectively reviewed. Tumours with a solid component (SC) size-to-whole tumour size (STR) ratio of 0, those with 0 < STR < 1 and those with an STR of 1 were defined as pure ground-glass tumours, PSTs and solid tumours (STs), respectively. RESULTS: Tumours with an SC diameter of >30 mm were less frequently observed among PSTs than among STs (4.83% vs 32.6%, P < 0.001). The postoperative 5-year survival of NSCLC patients with ground-glass tumour, PST and ST was 97.6%, 89.0% and 76.3%, respectively. In the survival analysis of patients with an SC diameter ≤30 mm, significant differences were observed among PST and ST (5-year survival, 90.7% vs 74.6%, P < 0.001). The multivariable analysis showed that age <70 years old, female sex, procedures with a lobectomy or more, SC size, pN0 disease and PST were independent predictors of a better survival among all PST and ST patients. CONCLUSIONS: Among patients with cT1 tumours, those with PST showed a significantly better survival than did those with ST. Small-sized PST tumours may not be suitable for the new cT descriptor.