Genome-wide association study of suicidal behaviour severity in mood disorders. (21st October 2021)

• Record Type: Journal Article
• Authors: Zai, Clement C.; Fabbri, Chiara; Hosang, Georgina M.; Zhang, Ruo Su; Koyama, Emiko; de Luca, Vincenzo; Tiwari, Arun K.; King, Nicole; Strauss, John; Jones, Ian; Jones, Lisa; Breen, Gerome; Farmer, Anne E.; McGuffin, Peter; Vincent, John B.; Kennedy, James L.; Lewis, Cathryn M.
• Is Part Of: World journal of biological psychiatry. Volume 22:Number 9(2021)
• Page Start: 722
• Page End: 731
• Publication Date: 2021-10-21
• Subjects: Suicidality; genome-wide association study; bipolar disorder; major depressive disorder; suicidal behaviour severity; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2021.1907711
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objective: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample ( n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes. Conclusions: Larger sample sizes are required to detect moderate effects.