The Impact of Cocirculating Pathogens on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Coronavirus Disease 2019 Surveillance: How Concurrent Epidemics May Introduce Bias and Decrease the Observed SARS-CoV-2 Percentage Positivity. (13th September 2021)

• Record Type: Journal Article
• Authors: Kovacevic, Aleksandra; Eggo, Rosalind M; Baguelin, Marc; Domenech de Cellès, Matthieu; Opatowski, Lulla
• Is Part Of: Journal of infectious diseases. Volume 225:Number 2(2022)
• Page Start: 199
• Page End: 207
• Publication Date: 2021-09-13
• Subjects: cocirculating respiratory viruses -- COVID-19 surveillance -- mathematical modeling -- multiplex testing -- SARS-CoV-2; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab459
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Circulation of seasonal non–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) respiratory viruses with syndromic overlap during the coronavirus disease 2019 (COVID-19) pandemic may alter the quality of COVID-19 surveillance, with possible consequences for real-time analysis and delay in implementation of control measures. Methods: Using a multipathogen susceptible-exposed-infectious-recovered (SEIR) transmission model formalizing cocirculation of SARS-CoV-2 and another respiratory virus, we assessed how an outbreak of secondary virus may affect 2 COVID-19 surveillance indicators: testing demand and positivity. Using simulation, we assessed to what extent the use of multiplex polymerase chain reaction tests on a subsample of symptomatic individuals can help correct the observed SARS-CoV-2 percentage positivity and improve surveillance quality. Results: We find that a non–SARS-CoV-2 epidemic strongly increases SARS-CoV-2 daily testing demand and artificially reduces the observed SARS-CoV-2 percentage positivity for the duration of the outbreak. We estimate that performing 1 multiplex test for every 1000 COVID-19 tests on symptomatic individuals could be sufficient to maintain surveillance of other respiratory viruses in the population and correct the observed SARS-CoV-2 percentage positivity. Conclusions: This study showed that cocirculating respiratory viruses can distort SARS-CoV-2 surveillance. Correction of the positivity rate can be achieved by using multiplex polymerase chain reaction tests, and a low number of samples is sufficient to avoid bias in SARS-CoV-2 surveillance. Abstract : Coronavirus disease 2019 surveillance indicators may be affected by increased cocirculation of other respiratory viruses delaying control measure implementation. Continued surveillance through multiplex polymerase chain reaction testing in a subsample of the symptomatic population may help fix this problem.