Hereditary Angioedema Type I Triggered by Dental Treatment: A Case Report and Review of the Literature. (2nd January 2022)

• Record Type: Journal Article
• Authors: Jagatiya, Yashoda; Yogarajah, Sangeetha; Monteiro, Luis; Carey, Barbara; Albuquerque, Rui
• Is Part Of: Dental update. Volume 49:Number 1(2022)
• Page Start: 57
• Page End: 62
• Publication Date: 2022-01-02
• Subjects: Dentistry -- Periodicals; 617.6
• DOI: 10.12968/denu.2022.49.1.57
• Languages: English
• ISSNs: 0305-5000

Abstract

Abstract : Type 1 hereditary angioedema (HAE) is a rare genetic condition characterized by recurrent episodes of oedema caused by a deficiency of C1-esterase inhibitor (C1-INH). A 29-year-old male presented to the oral medicine department at Guy's Hospital, London, with lip swelling following crown preparation and impressions. Haematological investigations showed reduced levels of complement C4 (0.02 g/L; reference range 0.1–0.4 g/L) and C1-INH function was <31% (reference range 85–99%). Immunology confirmed the diagnosis of type 1 HAE, with a de novo mutation. This case highlights how a detailed medical history and multidisciplinary teamwork ensure the correct diagnosis and management. CPD/Clinical Relevance: To demonstrate the various dental triggers, relevant signs and symptoms, and management options for patients diagnosed with hereditary angioedema to allow for effective decision-making in a primary dental setting.