Forensic application of a novel MPS-based panel (90 STRs and 100 SNPs) in a non-exclusion parentage case with three autosomal STRs incompatibilities. (February 2022)

• Record Type: Journal Article
• Authors: Wu, Jia-zi; Wang, Ling-xiang; Yang, Xing-yi; Pan, Dong-hua; Lu, Xiao-yu; Liu, Chang-hui; Han, Xiao-long; Liu, Hong; Shi, Mei-sen; Liu, Chao; Wen, Shao-qing
• Is Part Of: Legal medicine. Volume 54(2022)
• Publication Date: 2022-02
• Subjects: Autosomal STRs -- Mutation -- MPS -- Parentage testing -- SNPs; Medical jurisprudence -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Medical jurisprudence; Periodicals; 614.1
• DOI: 10.1016/j.legalmed.2021.101987
• Languages: English
• ISSNs: 1344-6223

Abstract

Highlights: We present a novel MPS-based panel (90 STRs and 100 SNPs) for the application of kinship tests. The MPS-based panel can provide additional allele sequence structures that can be used to infer the origins of the mutations. SNPs as supplementary markers can provide effective information to give an unequivocal statement of the parentage. Abstract: In kinship tests, the investigating of the forensic STRs usually provides decisive information to resolve relationship cases. We describe a parentage case with 3 genetic incompatibilities (D6S1043, D18S51 and D2S1338) between the child and alleged parent. With 90 STR loci and 100 SNP loci, the massively parallel sequencing (MPS)-based genotyping results support the certainty of parentage, and the mismatched alleles were considered to be mutations. MPS can provide additional allele sequence structures that can be used to infer the origins of the mutations. SNPs as supplementary markers can provide effective information to give an unequivocal statement of the parentage.