An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity. Issue 19 (2nd October 2019)

• Record Type: Journal Article
• Authors: Liang, Jia-Hao; Huo, Xiao-Kui; Cheng, Zhong-Bin; Sun, Cheng-Peng; Zhao, Jian-Chao; Kang, Xiao-Hui; Zhang, Tian-Yuan; Chen, Zhong-Jian; Yang, Tian-Mei; Wu, Ying-Ying; Deng, Xiao-Peng; Zhang, Yi-Xuan
• Is Part Of: Natural product research. Volume 33:Issue 19(2019)
• Page Start: 2770
• Page End: 2776
• Publication Date: 2019-10-02
• Subjects: Drechmeria sp. -- indole diterpenoid -- antimicrobial activity -- molecular docking; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1501050
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new indole diterpenoid, drechmerin I (1 ), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng . Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1 ) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1 ) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1 ) was investigated by molecular docking. Graphical Abstract: