Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11. (1st February 2022)

• Record Type: Journal Article
• Authors: Jang, Jun-Pil; Jang, Mina; Hwang, Gwi Ja; Kim, Min Hee; Ahn, Jong Seog; Ko, Sung-Kyun; Jang, Jae-Hyuk
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 57(2022)
• Publication Date: 2022-02-01
• Subjects: Secondary metabolites -- Streptomyces sp. -- Fusicoccane-type diterpenoids -- Autophagy; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2021.128504
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two new fusicoccane-type diterpenoids, streptooctatins A (1 ) and B (2 ), together with a known compound cyclooctatin (3 ) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity.