Scaling laws and the left main coronary artery bifurcation. A combination of geometric and simulation analyses. (January 2022)

• Record Type: Journal Article
• Authors: Blanco, Pablo J.; dos Santos, Gabriela H. Vargas; Bulant, Carlos A.; Alvarez, Alonso M.; Oliveira, Fredric A.P.; Cunha-Lima, Gabriella; Lemos, Pedro A.
• Is Part Of: Medical engineering & physics. Volume 99(2022)
• Publication Date: 2022-01
• Subjects: Coronary arteries -- Allometric laws -- Angiography -- Vascular geometry -- Blood flow -- Simulation; Biomedical engineering -- Periodicals; Biomedical Engineering -- Periodicals; Physics -- Periodicals; Génie biomédical -- Périodiques; Biomedical engineering; Electronic journals; Periodicals; 610.28
• DOI: 10.1016/j.medengphy.2021.08.011
• Languages: English
• ISSNs: 1350-4533

Abstract

Highlights: Comparison of in-vivo coronary vessel diameter with existing scaling laws. Assessment of different power-law criteria in the characterization of blood flow models. Novel approach to enforce matching between averaged wall shear stresses in branching vessels. Huo-Kassab's criterion results in improved shear stress balancing between branching vessels. Abstract: The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of 7 / 3 results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.