Cardiac cysticercosis and neurocysticercosis in sudden and unexpected community deaths in Lusaka, Zambia: a descriptive medico-legal post-mortem examination study. (February 2022)

• Record Type: Journal Article
• Authors: Himwaze, Cordilia; Mucheleng'anga, Luchenga Adam; Telendiy, Victor; Hamukale, Amos; Tembo, John; Kapata, Nathan; Ntoumi, Francine; Zumla, Alimuddin
• Is Part Of: International journal of infectious diseases. Volume 115(2022)
• Page Start: 195
• Page End: 200
• Publication Date: 2022-02
• Subjects: Cysticercosis -- Cardiac -- Heart -- Brain -- Forensic autopsy -- Community deaths -- Neurocysticercosis -- Cardiac cysticercosis -- Zambia -- Africa; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.11.042
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Cysticercosis is a neglected human zoonosis worldwide. Reports of cardiac cysticercosis causing sudden community deaths are rare. Forensic autopsies of unexpected deaths can reveal undetected cysticercosis. Cardiac cysticercosis is an important differential to consider in sudden deaths. Abstract: Background: Cysticercosis is a World Health Organization designated neglected human zoonosis worldwide. Data on cardiac cysticercosis and its contribution to sudden and unexpected community deaths are scarce and require study. Methods: A study was performed of cysticercosis-related deaths and other incidental cases of cysticercosis seen at forensic post-mortem examination over a period of 12 months, in individuals who died suddenly and unexpectedly in the community in Lusaka, Zambia. Whole-body post-mortem examinations were performed according to standard operating procedures for post-mortem examinations. Representative samples were obtained from all body organs and subjected to histopathological examination. Information was obtained on circumstances surrounding the death. Data were collated on patient demographics, history, co-morbidities, pathological gross and microscopic findings, and forensic autopsy cause(s) of death. The available literature on cardiac cysticercosis was also reviewed. Results: Nine cases of cysticercosis were identified. Eight of the nine cases had cardiac cysticercosis. There was no prior history of cysticercosis before death. All were male, aged between 28 and 56 years, and from high population density and low socioeconomic communities. There was no community case clustering identified. Conclusions: Cardiac cysticercosis and neurocysticercosis are important incidental findings in sudden and unexpected deaths in the community and can easily be missed antemortem. More investment in forensic autopsy services is required to define the undiagnosed burden of deaths due to treatable communicable diseases.