Cu-catalyzed coupling of unactivated tertiary alkyl alcohols with thiols via C–O bond cleavage. (19th January 2022)

• Record Type: Journal Article
• Authors: Xu, Bing; Ye, Yang; Lin, Ying; Bai, Renren; Ye, Xiang-Yang; Xie, Tian
• Is Part Of: Tetrahedron letters. Volume 89(2022)
• Publication Date: 2022-01-19
• Subjects: Copper -- Tertiary alkyl alcohol -- C–S bond -- Cross-coupling -- Quaternary carbon center; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153604
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstarct: Herein we present the plain manufacture of sterically hindered tertiary alkyl thioethers via the Cu-catalyzed coupling of unactivated tertiary alkyl alcohols with thio-alcohols/phenols. The present strategy with easy-to-operate reaction conditions represents one of the most effective unactivated tertiary C(sp 3 )–S bond-forming methods via readily accessible Lewis acid catalysis. Moreover, this protocol has high functional group compatibility and wide substrate adaptability.