Brazilian network of COVID-19 during pregnancy (REBRACO: a multicentre study protocol). Issue 12 (17th December 2021)

• Record Type: Journal Article
• Authors: Costa, Maria Laura; Souza, Renato T; Pacagnella, Rodolfo C; Bento, Silvana F; Ribeiro-do-Valle, Carolina C; Luz, Adriana G; Lajos, Giuliane J; Mazon, Silvia B; Bahamondes, Luis; Surita, Fernanda G; Nobrega, Guilherme M; Griggio, Thayna B; Charles, Charles M'poca; Miele, Maria J; Tedesco, Ricardo P; Fernandes, Karayna G; Martins-Costa, Sergio; Peret, Frederico JA; Feitosa, Francisco E; Mattar, Rosiane; Traina, Evelyn; Cunha Filho, Edson V; Vettorazzi, Janete; Haddad, Samira M; Andreucci, Carla B; Guida, José Paulo; Correa Junior, Mario D; Dias, Marcos Augusto Bastos; Oliveira, Leandro G; Melo Junior, Elias F; Menezes, Carlos AS; Luz, Marília GQ; Cecatti, Jose Guilherme;
• Other Names: author non-byline.; Metelus Sherly author non-byline.; Castro Lester author non-byline.; Pabon Stephanie author non-byline.; Soeiro Rachel author non-byline.; Silva Amanda D author non-byline.; Junior Paulo S R author non-byline.; Sardinha Thais G author non-byline.; Japenga Rodolfo R author non-byline.; Urquiza Erica R F author non-byline.; Machado Maíra R author non-byline.; Simões Marcela Maria author non-byline.; Solda Larissa M author non-byline.; Mayrink Jussara author non-byline.; Yazaki-Sun Sue author non-byline.; Mota Priscilla author non-byline.; Soares Arimaza C author non-byline.; Machado Ellen author non-byline.; Bergmann Anne author non-byline.; Santos Gustavo Raupp dos author non-byline.; Peres Patrícia B author non-byline.; Arbeli Cristiane L author non-byline.; Quevedo Rafael M author non-byline.; Yamashita Carolina F author non-byline.; Corradin Julia D author non-byline.; Bergamini Isabella author non-byline.; L Ramos José Geraldo author non-byline.; R Oppermann Maria Lúcia author non-byline.; Quadro Laisa S author non-byline.; Marins Lina author non-byline.; Paniz Érika V author non-byline.; Xavier Thaís Vicentini author non-byline.; Parreira Bruna E author non-byline.; Tosetto Aline author non-byline.; Savazoni Sabrina author non-byline.; Costa Aline C author non-byline.; Almeida Marina HL author non-byline.; Moura Bruna FV author non-byline.; França Lidiane R author non-byline.; Vieira Hanna author non-byline.; B Aquino Rafael author non-byline.; Leite Débora F author non-byline.; Monteiro Isabella author non-byline.; Nakamura-Pereira Marcos author non-byline.; Guerra Bruna O author non-byline.; Gorga Gabriela author non-byline.; Pinheiro Daisy author non-byline.; Cordeiro Denise author non-byline.; Miná Priscila L author non-byline.; Dornellas Carol author non-byline.; Oliveira Kevin FA author non-byline.; Leal Caio author non-byline.; Amana Rayra author non-byline.; Santos Cristiane O author non-byline.; dos Santos Marina M author non-byline.; Neto Carlos author non-byline.; Gomes Thiago author non-byline.; Pereira Isabela R author non-byline.; Salustrino Clélia Andrade author non-byline.; Pontes Valéria B author non-byline.; da Silva Franco Roberto Allen author non-byline.; Bilibio João Paolo author non-byline.; Brito Gislânia PF author non-byline.; C Pinto Hana Paula author non-byline.; de Oliveira Danielle Leal author non-byline.; Guerra Andrezza A author non-byline.; Moura Andrea O author non-byline.; Pantoja Natasha author non-byline.; David Fernanda author non-byline.; Silva Alina author non-byline.; Freitas-Jesus Juliana Vasconcellos author non-byline.; Bacha Angela M author non-byline.; Borovac-Pinheiro Anderson author non-byline.; Pereira Belmiro G author non-byline.; Amaral Eliana M author non-byline.; Ferreira Elton Carlos author non-byline.; Milanez Helaine MBPM author non-byline.; Caldas Jamil P S author non-byline.; Baccaro Luiz F author non-byline.; Nomura Marcelo L author non-byline.; Rehder Patrícia M author non-byline.; Simone Renata Z author non-byline.; Passini Jr Renato author non-byline.; Torrezan Cristiano author non-byline.; Modena Jose L P author non-byline.; Nunes dos Santos Magnun N author non-byline.; Marba Sergio T M author non-byline.; Dias Tabata Z author non-byline.; EV Mariana author non-byline.;
• Is Part Of: BMJ open. Volume 11:Issue 12(2021)
• Publication Date: 2021-12-17
• Subjects: COVID-19 -- infection control -- prenatal diagnosis -- maternal medicine -- qualitative research; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-051284
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: The aim of this study was to evaluate the clinical, epidemiological and laboratory aspects of SARS-CoV-2 infection during pregnancy and postpartum in 16 maternity hospitals. Methods and analysis: A prospective multicentre study, with five axes. First, the prevalence of SARS-CoV-2 infection among women admitted for childbirth will be described in a cross-sectional study. Second, maternal and perinatal outcomes will be assessed in a prospective cohort study including pregnant or postpartum women with suspected COVID-19. Third, a cohort of positive COVID-19 cases with sampling of a variety of biological material. Histopathological and viral analysis of biological maternal and neonatal samples will be performed, and the assessment of nutritional variables to evaluate the association between vitamin D and severity of infection. Fourth, a monitoring and evaluation committee to collect relevant healthcare information and plan actions in centres facing the pandemic. Furthermore, qualitative studies will be performed to study pregnant women, their families and health professionals. Fifth, an ecological study will monitor the number of live births, stillbirths and other outcomes to explore any trend among the periods before, during and after the pandemic. Data will systematically be collected in an electronic platform following standardised operational procedures. For quantitative study components, an appropriate statistical approach will be used for each analysis. For qualitative data, in-depth interviews recorded in audio will be transcribed, checking the text obtained with the recording. Subsequently, thematic analysis with the aid of the NVivo programme will be performed. Ethics and dissemination: Ethical approval was obtained (letters of approval numbers 4.047.168, 4.179.679 and 4.083.988). All women will be fully informed to sign the consent form before enrolment in the study. Findings will be disseminated through peer-reviewed journals and scientific conferences.